A Retrospective Study on Gloriosa superbaand Its Main Active Constituents

Author:

Shriwastava Aishwarya1ORCID,Chopra Vijay1ORCID,Vyas Manish1ORCID,Khatik Gopal L.2ORCID,Yadav Pramod3ORCID,Gupta Jeena4ORCID,Singh Amrit Pal1ORCID

Affiliation:

1. Department of Ayurveda, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India

2. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India

3. Department of Rasashastra & Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, India

4. Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India

Abstract

BackgroundGloriosa superba: L. (G. superba) is a perennial creeper and climbs up to 5-7 meters. It belongs to the Liliaceae family and is native to Africa and South-East Asia. It is also categorized as an endangered plant which may be due to its extensive use. Objective: The objective of the present review is to explore anticancer potential with other pharmacological activities of G. superba and its active constituents. Results: G. superba has been reported to have many chemical constituents including colchicine, β- sitosterol, glumicolchicine, b-lumicolchicine, 2-OH-6-MeO-benzoic acid, glorisine, tannins, colchicoside, cornigerine, and many more. Most of them are effective against cancer, gout, arthritis, ulcers, bleeding piles, impotence, snakebites, skin diseases, and leprosy. G. superba has also been reported to possess pharmacological activities like anticancer, anti-inflammatory, antioxidant, abortifacient, anti-ulcerogenic, anti-helminthic and antimicrobial. Conclusion: The present review summarizes the anticancer potential of G. superba and its constituents. However, a detailed study is required to establish it as an effective anticancer drug.

Publisher

Bentham Science Publishers Ltd.

Subject

Complementary and alternative medicine,Drug Discovery

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