Affiliation:
1. Department of Horticultural Science, College of Agriculture, Shiraz University, Shiraz, Iran
Abstract
Metabolomics is widely applied for investigation of the correlation between metabolites
and genes responsible for the synthesis of the particular sets of metabolites. In this review, we discuss
metabolomics research on Hypericum perforatum (St. John’s Wort) to elucidate the overall
regulation of the metabolism related to the mechanisms of natural variations and environmental
stresses such as fungal infections, light stresses, and chemical elicitors. We also focus on phytochemical
genomics and genomic information. St. John’s Wort is a medicinal plant with high potential
of producing hypericin used for mild depression remedy, so knowledge on the biosynthetic
pathway of unique metabolites is fundamental for their biotechnological commercial production.
These metabolites have often complex biosynthetic pathway and it is challenging to identify all of
the catalyzing enzymes. The development of metabolic systems biology could open new channels
for high-speed construction and evaluation of hypotheses for cellular regulatory systems.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
Reference37 articles.
1. He M.; Wang Y.; Hua W.; Zhang Y.; Wang Z.;
De novo sequencing of Hypericum perforatum transcriptome to identify potential genes involved in the biosynthesis of active metabolites. PLoS One 2012,7(7),1-10
2. Saddiqe Z.; Naeem I.; Maimoona A.; A review of the antibacterial activity of Hypericum perforatum L. J Ethnopharmacol 2014,131,511-521
3. Kosuth J.; Smelcerovic A.; Borsch T.; Zuehlke S.; Karppinen K.; Spiteller M.; Hohtola A.; Cellarova E.; The hyp-1 gene is not a limiting factor for hypericin biosynthesis in the genus Hypericum. Func. Plant Biol 2011,38,35-43
4. Porzel A.; Farag M.A.; Mulbradt J.; Wessjohann L.A.; Metabolite profiling and fingerprinting of Hypericum Species: A comparison of MS and NMR metabolomics. Metabolomics 2014,10,574-588
5. Velada I.; Ragonezi C.; Schmitt B.A.; Cardoso H.; Reference genes selection and normalization of oxidative stress responsive genes upon different temperature stress conditions in Hypericum perforatum L. PLoS One 2014,9(12),1-24