Affiliation:
1. Department of Biotechnology, Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Egypt
2. Department of Biotechnology, Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA),
Egypt
3. Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt
Abstract
Background:
Seafood is an important source of food for the majority of people. Marine
species have a wide spectrum of pharmacological actions, including antibacterial, antiviral, antiparasitic,
anti-inflammatory, and anti-diabetic properties.
Objective:
The purpose of this study was to examine the effects of Sepia officinalis extract (SoE) on
folic acid-induced acute kidney injury in Wistar rats.
Methods:
A single dosage of folic acid (250 mg/kg) was injected intraperitoneally to cause kidney
injury induced (AKI). The study contained three groups of six rats each: control, folic acid, and folic
acid + SoE groups. The SoE group received SoE (45 mg/kg, orally) daily for one week, while
the control and folic acid groups were administered distilled water.
Results:
The crude extract of Sepia officianlis contains heavy metals such as Fe, Cr, Cd, Pb, and
Zn, according to our findings. The LD50 value of SoE was 450 mg/kg. SoE treatment increases creatinine,
urea, uric acid, sodium, potassium, chloride, aspartate aminotransferase, alanine aminotransferase,
alkaline phosphatase, gamma-glutamyltransferase, malondialdehyde, and nitric oxide
levels while decreasing total proteins, albumin, glutathione reduced, glutathione-S-transferase, and
catalase. Several histological alterations were found in the liver and kidney of the SoE rats.
Conclusion:
The heavy metal content of S. officinalis extract has a synergistic effect with folic acid
to induce hepatorenal injury. Natural extracts of marine species should be used with caution as a
component of medications or natural remedies.
Publisher
Bentham Science Publishers Ltd.
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