Investigation of the Effect of Loratadine and Calcium Ions on Oxidoreductase Activity of Catalase Enzyme-Reference-Cited by-同舟云学术

Investigation of the Effect of Loratadine and Calcium Ions on Oxidoreductase Activity of Catalase Enzyme

Published:2021-01 Issue:1 Volume:17 Page:26-32
ISSN:1573-4080
Container-title:Current Enzyme Inhibition
language:en
Short-container-title:CEI

Author:

Hasković Edhem¹,Herenda Safija²,Halilović Zehra¹,Unčanin Snežana³,Hasković Denis⁴,Deljkić Ena⁵

Affiliation:

1. Department of Biology, Faculty of Science, University of Sarajevo, Zmaja od Bosne 33-35, 71000 Sarajevo,Bosnia and Herzegovina

2. Department of Chemistry, Faculty of Science, University of Sarajevo, Zmaja od Bosne 33-35, 71000 Sarajevo,Bosnia and Herzegovina

3. Clinical Center, University of Sarajevo, Clinic of Nephrology, Bolnička 25, 71 000 Sarajevo,Bosnia and Herzegovina

4. Clinical Center, University of Sarajevo, Organizational Unit Clinical Pathology, Cytology and Human Genetics, Bolnicka 25, 71000 Sarajevo,Bosnia and Herzegovina

5. Clinical Center, University of Sarajevo, Organizational Unit Clinical Biochemistry with Immunology, Bolnička 25, 71 000 Sarajevo,Bosnia and Herzegovina

Abstract

Background: The Spectrophotometric method is one of the most suitable analytical techniques for testing the activity of enzymes under the influence of various factors. Methods: The effect of H1-antihistamines of loratadine and calcium ions on enzyme catalase under in vitro conditions was investigated in this paper. Results and Discussion: It has been shown that loratadine is a partial inhibitor of catalase, but this effect is diminished in the presence of calcium ions. Calcium as well as other cations are important for many biological and cellular functions. The kidneys play a central role in the homeostasis of these ions. The activity of the catalase enzyme under the given conditions, the type of inhibition, and the kinetic parameters of the enzyme reaction were determined. Conclusion: We concluded that loratadine is a partially competitive inhibitor.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Molecular Medicine,Biochemistry

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