Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction-Reference-Cited by-同舟云学术

Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction

Published:2022-08 Issue:5 Volume:23 Page:326-336
ISSN:1389-2029
Container-title:Current Genomics
language:en
Short-container-title:CG

Author:

Kamath Mohan S.¹^ORCID,Kamath Vandana²,Chacko Mary Purna²

Affiliation:

1. Department of Reproductive Medicine and Surgery, Christian Medical College, Vellore 632004, India

2. Department of Cytogenetics, Christian Medical College, Vellore 632004, India

Abstract

Abstract: In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal screening tool, it has gained recognition for its sensitivity and specificity in the detection of common aneuploidies. This review mainly focuses on the emerging role of NIPT in pregnancies following assisted reproductive technology (ART) in the light of current evidence and recommendations. It also deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies, with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded as the Achilles’ heel of most pre-natal screening platforms. Future directions for exploration towards improving the performance and extending the scope of NIPT are also addressed.

Publisher

Bentham Science Publishers Ltd.

Subject

Genetics (clinical),Genetics

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