Identification of Novel Molecular Network Expression in Acute Myocardial Infarction-Reference-Cited by-同舟云学术

Identification of Novel Molecular Network Expression in Acute Myocardial Infarction

Published:2019-12-03 Issue:5 Volume:20 Page:340-348
ISSN:1389-2029
Container-title:Current Genomics
language:en
Short-container-title:CG

Author:

Matboli Marwa¹,Shafei Ayman E.²,Agwa Sara H.A.³,Elzahy Sherif Sammir⁴,Anwar Ahmed K.⁵,Mansour Amr R.⁵,Gaber Ahmed I.⁵,Said Ali E.A.⁵,Lwis Paula⁵,Hamdy Marwa¹

Affiliation:

1. Medicinal Biochemistry and Molecular Biology Department, Ain Shams University, Faculty of Medicine, Cairo, Egypt

2. Biomedical Research Department, Military Medical Academy, Cairo, Egypt

3. Clinical Pathology, Medical Ain Shams Research Institute (MASRI), Cairo, Egypt

4. Cardiovascular Medicine Department, Ain Shams University, Faculty of Medicine, Cairo, Egypt

5. Armed Forces College of Medicine, Cairo, Egypt

Abstract

Background:In the current study, we aimed to analyze the hypothesis that human myocardial- specific extracellular RNAs expression could be used for acute myocardial injury(AMI) diagnosis.Methodology:We used bioinformatics’ analysis to identify RNAs linked to ubiquitin system and specific to AMI, named, (lncRNA-RP11-175K6.1), (LOC101927740), microRNA-106b-5p (miR-106b- 5p) and Anaphase, promoting complex 11 (ANapc11mRNA). We measured the serum expression of the chosen RNAs in 69 individuals with acute coronary syndromes, 31 individuals with angina pectoris without MI and non-cardiac chest pain and 31 healthy control individuals by real-time reversetranscription PCR.Results:Our study revealed a significant decrease in both lncRNA-RP11-175K6.1 and ANapc11mRNA expression of in the sera samples of AMI patients compared to that of the two control groups alongside with significant upregulation of miR-106b-5p.Conclusion:Of note, the investigated serum RNAs decrease the false discovery rate of AMI to 3.2%.

Funder

Egyptian Science and Technology Development Fund

Publisher

Bentham Science Publishers Ltd.

Subject

Genetics (clinical),Genetics

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