Effects of Standardized Aqueous Ethanolic Extract of Leaves of Ficus Deltoidea var. Trengganuensis on Blood Pressure in Spontaneously Hypertensive Rats

Author:

Radjeni Zurain1,Abdul Aziz Mardiana1,Ab Azis Norasikin1,Ahmad Kamal Mohd Saleh2,Singh Harbindar Jeet134

Affiliation:

1. Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, Sungai Buloh Campus, Selangor, Malaysia

2. Faculty of Dentistry, Lincoln University College, 47301 Petaling Jaya, Selangor, Malaysia

3. Institute For Medical Molecular Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Cawangan Selangor, Sungai Buloh Campus, Selangor, Malaysia

4. Institute for Pathology, Laboratory and Forensic Medicine (I-PPerFORM), Universiti Teknologi MARA, Cawangan Selangor, Sungai Buloh Campus, Selangor, Malaysia

Abstract

Background: Laboratory evidence pertaining to the antihypertensive activity of a number of Ficus deltoidea (FD) varieties remains undetermined, although extracts of some of these varieties have been shown to have angiotensin-converting enzyme (ACE) inhibitory activity in vitro. Objective: This study, therefore, evaluated the effect of a standardized aqueous-ethanolic extract of leaves of Ficus deltoidea var. trengganuensis (FDT) on blood pressure in spontaneously hypertensive rats (SHR). Methods: SHR were given either to 800, 1000 or 1200 mg kg-1 body weight of standardized aqueous- ethanolic extract of FDT or 10 mg kg-1 body weight of losartan or 0.5 ml of distilled water daily for four weeks. Results: SBP decreased significantly in FDT- and losartan-treated rats (p < 0.05). Components of RAAS and other serum and urinary parameters were not different between the groups except for Endothelin-1, which was significantly lower than that in the controls. Urinary calcium excretion was significantly higher in FDT-treated rats (p < 0.05). Conclusion: It seems that daily oral administration of FDT significantly lowers blood pressure in SHR through mechanisms that do not involve RAAS but may involve the endothelium or other yetto- be-determined mechanisms.

Funder

Ministry of Agriculture and Agro-based Industry

Publisher

Bentham Science Publishers Ltd.

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