Recent Progress of Machine Learning in Gene Therapy

Author:

Hunt Cassandra1,Montgomery Sandra2,Berkenpas Joshua William1,Sigafoos Noel1,Oakley John Christian1,Espinosa Jacob3,Justice Nicola4,Kishaba Kiyomi5,Hippe Kyle1,Si Dong6,Hou Jie7,Ding Hui8,Cao Renzhi1ORCID

Affiliation:

1. Department of Computer Science, Pacific Lutheran University, Tacoma, WA, United States

2. Department of Physics, Pacific Lutheran University, Tacoma, WA, United States

3. Department of Mathematics, Pacific Lutheran University, Tacoma, WA, United States; dDepartment of Humanities, Pacific Lutheran University, Tacoma, WA, United States

4. Department of Mathematics, Pacific Lutheran University, Tacoma, WA, United States

5. Department of Humanities, Pacific Lutheran University, Tacoma, WA, United States

6. Division of Computing Software Systems, University of Washington-Bothell, Bothell, WA, United States

7. Department of Computer Science, Saint Louis University, St. Louis, MO, United States

8. School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China

Abstract

: With new developments in biomedical technology, it is now a viable therapeutic treatment to alter genes with techniques like CRISPR. At the same time, it is increasingly cheaper to do whole genome sequencing, resulting in rapid advancement in gene therapy and editing in precision medicine. Thus, understanding the current industry and academic applications of gene therapy provides an important backdrop to future scientific developments. Additionally, machine learning and artificial intelligence techniques allow for the reduction of time and money spent in the development of new gene therapy products and techniques. In this paper, we survey the current progress of gene therapy treatments for several diseases and explore machine learning applications in gene therapy. We also discuss the ethical implications of gene therapy and the use of machine learning in precision medicine. Machine learning and gene therapy are both topics gaining popularity in various publications, and we conclude that there is still room for continued research and application of machine learning techniques in the gene therapy field.

Publisher

Bentham Science Publishers Ltd.

Subject

Genetics (clinical),Drug Discovery,Genetics,Molecular Biology,Molecular Medicine

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