Correlation between MDSC and Immune Tolerance in Transplantation: Cytokines, Pathways and Cell-cell Interaction-Reference-Cited by-同舟云学术

Correlation between MDSC and Immune Tolerance in Transplantation: Cytokines, Pathways and Cell-cell Interaction

Published:2019-08-20 Issue:2 Volume:19 Page:81-92
ISSN:1566-5232
Container-title:Current Gene Therapy
language:en
Short-container-title:CGT

Author:

Yang Tianying¹,Li Jiawei¹,Li Ruimin¹,Yang Chunchen²,Zhang Weitao¹,Qiu Yue³,Yang Cheng¹,Rong Ruiming¹

Affiliation:

1. Shanghai Key Laboratory of Organ Transplantation, Shanghai, China

2. Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China

3. Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China

Abstract

MDSCs play an important role in the induction of immune tolerance. Cytokines and chemokines (GM-CSF, IL-6) contributed to the expansion, accumulation of MDSCs, and MDSCs function through iNOS, arginase and PD-L1. MDSCs are recruited and regulated through JAK/STAT, mTOR and Raf/MEK/ERK signaling pathways. MDSCs’ immunosuppressive functions were realized through Tregs-mediated pathways and their direct suppression of immune cells. All of the above contribute to the MDSC-related immune tolerance in transplantation. MDSCs have huge potential in prolonging graft survival and reducing rejection through different ways and many other factors worthy to be further investigated are also introduced.

Publisher

Bentham Science Publishers Ltd.

Subject

Genetics (clinical),Drug Discovery,Genetics,Molecular Biology,Molecular Medicine

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