Affiliation:
1. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract
Abstract:
Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides
that act by targeting translational and post-translational modifications, epigenetic regulators, and
chromatin remodeling complexes. There has been increasing evidence that the lncRNA X-inactive
specific transcript (lncRNA Xist) via targeting miRNAs and transcription factors plays a critical role
in cell growth, proliferation, and differentiation. This lncRNA also has an important role in the progression
of tumors and other human diseases by acting as a competing endogenous RNA (ceRNA).
Accumulating evidence revealed that lncRNA Xist by targeting several signaling pathways is involved
in the pathogenesis of gynecologic cancers. In this review, we focused on the recent functions
of lncRNA Xist in breast, cervical, and ovarian cancers.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Oncology,Molecular Medicine
Cited by
1 articles.
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