Affiliation:
1. Department of Microbiology, Karaj Branch Islamic Azad University, Karaj, Iran
2. Department of Neuroscience, School
of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract
Background:
NMDA receptors have a significant role in the development of opioid physical
dependence. Evidence demonstrated that a drug of abuse enhances neuronal excitability in the Paraventricular
Nucleus (PVT). The current research studied whether blocking NMDA receptors through
the administration of MK801 in the PVT nucleus could affect the development of Morphine (Mor) dependence
and hence the behavioral indices induced by morphine withdrawal in rats.
Methods:
Male Wistar rats weighing 250-300 g were used. For induction of drug dependence, we injected
Mor subcutaneously (s.c.) (6, 16, 26, 36, 46, 56, and 66 mg/kg, 2 ml/kg) at an interval of 24
hours for 7 days. Animals were divided into two groups in which the NMDA receptor antagonist,
MK801 (20 mM in 0.1 ml), or its vehicle were applied into the PVT nucleus for 7 days before each
Mor administration. On day 8, after injection of naloxone (Nal, 2.5 mg/kg, i.p.), withdrawal behaviors
were checked for 25 min.
Results:
The current results demonstrated that the blockade of the NMDA receptor in the PVT nucleus
significantly increased withdrawal behaviors provoked by the application of Nal in morphinedependent
(Mor-d) rats.
Conclusion:
We concluded that the NMDA receptor in the PVT nucleus changes the development of
Mor dependence.
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Medicine,Neuropsychology and Physiological Psychology,General Neuroscience
Cited by
1 articles.
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