Affiliation:
1. Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
2. Department of Obstetrical-Gynecological Sciences and Urologic Sciences, Sapienza University of Rome, Italy
3. Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy
Abstract
Introduction:
Chronic Kidney Disease (CKD) is a highly prevalent condition and it is a
major risk factor for End-Stage Renal Disease (ESRD), cardiovascular disease, and premature
death. Some congenital and acquired anomalies of the kidneys and lower urinary tract (CAKUT
and CALUT) are well-known causes of CKD and ESRD, but often remain undiagnosed and their
prevalence is underestimated. This study aims to provide an overview that considered mainly
some of the major congenital and acquired urological diseases that could lead to renal clinical
manifestations common even to the most widespread renal pathologies, for which often underdiagnosed.
Materials and Methods:
PubMed search was conducted for available English literature describing
the actual knowledge on congenital and acquired urological disorders determining acute and
chronic kidney disease. Prospective and retrospective studies as well as meta-analyses and latest
systematic reviews were included.
Results:
Most of the studies examined and reviewed were discarded for wrong population or intervention
or deemed unfit, and only 87 met the inclusion criteria for the review. The studies included
in the review related to urological disorders that may determine chronic and acute kidney
disease.
Conclusion:
Some urological diseases, as CAKUT and CALUT, especially in adults, show symptoms,
as renal failure, proteinuria and hypertension, very common to other kidney diseases, for
this reason may remain undiagnosed and their prevalence is not completely known. Therefore, in
doubtful cases, non-invasive and inexpensive tests, as cystourethrogram, should be made, to rule
out urological disorders and if necessary, ultrasonography, urography and scintigraphy, might allow
a correct and early diagnosis of these defects and thus adequate therapy, preventing or at least
slowing down an evolution toward CKD and ESRD.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Endocrinology
Reference108 articles.
1. Coresh J.; Astor B.C.; Greene T.; Prevalence of chronic kidneys disease and decreased kidney function in the adult US population: Third NANHES. Am J Kidney Dis 2003,41,1-12
2. De Nicola L.; Donfrancesco C.; Minutolo R.; Epidemiologia della MRC in Italia: Stato dell’arte e contributo dello studio CHARES. G Ital Nefrol 2011,28(4),401-407
3. Wood E.G.; Hand M.; Briscoe D.M.; North American Pediatric Renal Transplant Cooperative Study. Risk factors for mortality in infants and young children on dialysis. Am J Kidney Dis 2001,37(3),573-579
4. Wasilewska A.; Taranta-Janusz K.; Dębek W.; Zoch-Zwierz W.; Kuroczycka-Saniutycz E.; KIM-1 and NGAL: New markers of obstructive nephropathy. Pediatr Nephrol 2011,26(4),579-586
5. Yousefichaijan P.; Dorreh F.; Rafeie M.; Congenital anomalies of kidney and upper urinary tract in children with congenital hypothyroidism; a case-control study. J Renal Inj Prev 2015,4(4),120-126