Statin Use and Hepatocellular Carcinoma Risk: A Comprehensive Meta- Analysis and Systematic Review-Reference-Cited by-同舟云学术

Statin Use and Hepatocellular Carcinoma Risk: A Comprehensive Meta- Analysis and Systematic Review

Published:2024-01-26 Issue: Volume:19 Page:
ISSN:1574-8928
Container-title:Recent Patents on Anti-Cancer Drug Discovery
language:en
Short-container-title:PRA

Author:

Hashemi Rafsanjani Mahmood Reza¹^ORCID,Rahimi Rasoul²^ORCID,Heidari-Soureshjani Saeid³,Darvishi Mohammad⁴,Adeli Omid-Ali⁵⁶,Abbaszadeh Saber⁷

Affiliation:

1. Researcher and General Practitioner, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

2. Department of Surgery, Shahrekord University of Medical Sciences, Shahrekord, Iran

3. Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

4. Infectious Diseases and Tropical Medicine Research Center (IDTMRC), School of Aerospace and Subaquatic Medicine, Aja University of Medical Sciences, Tehran, Iran

5. Department of Pathology, Lorestan University of Medical Sciences, Khorramabad, Iran

6. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

7. Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Abstract

Background: Hepatocellular Carcinoma (HCC) is a public health problem around the world. Several studies have investigated the association between statin use and the risk of HCC, however, more studies are needed in this field. Objectives: This systematic review and meta-analysis aimed to investigate the relationship between statin use and HCC risk. Methods: Systematic searches of Web of Science, Scopus, PubMed, Cochrane, Science Direct, and Embase were conducted for studies published between 1980 and September 2023. Metaanalyses were performed using Stata 15 with a significance level of 0.05. Results: The search retrieved 8,125 articles, of which 40 were included in the meta-analysis after applying eligibility criteria. The total sample was 5,732,948 participants, including 68,698 HCC cases. Statin use was associated with a 44% lower risk of HCC compared to non-use (RR 0.56, 95% CI 0.50–0.63, p < 0.001). The RR was 0.54 (0.42-0.69) in American countries, 0.52 (0.44-0.62) in Asian countries, and 0.63 (0.48-0.84) in European countries. The RR was 0.50 (0.42-0.60) in studies with a mean age <50 years and 0.61 (0.53-0.70) in studies with a mean age ≥50 years. No evidence of publication bias was found (Begg’s test p = 0.718). Conclusion: This meta-analysis found statin use is associated with a significantly lower HCC risk. Statins may be a promising preventive intervention against HCC

Publisher

Bentham Science Publishers Ltd.