Affiliation:
1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad,
India
2. Department of Pharmacy, Birla Institute of Technology and Science Pilani (BITS PILANI), Pilani, Rajasthan,
India
Abstract
Background:
The Hot Melt Extrusion (HME) technique has shown tremendous potential in
transforming highly hydrophobic crystalline drug substances into amorphous solids without using solvents.
This review explores in detail the general considerations involved in the process of HME, its
applications and advances.
Objective:
The present review examines the physicochemical properties of polymers pertinent to the
HME process. Theoretical approaches for the screening of polymers are highlighted as a part of successful
HME processed drug products. The critical quality attributes associated with the process of
HME are also discussed in this review. HME plays a significant role in the dosage form design, and
the same has been mentioned with suitable examples. The role of HME in developing several sustained
release formulations, films, and implants is described along with the research carried out in a
similar domain.
Methods:
The method includes the collection of data from different search engines like PubMed, ScienceDirect,
and SciFinder to get coverage of relevant literature for accumulating appropriate information
regarding HME, its importance in pharmaceutical product development, and advanced applications.
Results:
HME is known to have advanced pharmaceutical applications in the domains related to 3D
printing, nanotechnology, and PAT technology. HME-based technologies explored using Design-of-
Experiments also lead to the systematic development of pharmaceutical formulations.
Conclusion:
HME remains an adaptable and differentiated technique for overall formulation development.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering
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