Affiliation:
1. Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences & Research Centre, Amrita
Vishwa Vidyapeetham, Kochi, Kerala, India
Abstract
Background:
Drug laden implantable systems can provide drug release over several hours
to years, which eventually aid in the therapy of both acute and chronic diseases. The present study focuses
on a fundamental evaluation of the influence of implant properties such as morphology, architecture,
porosity, surface area, and wettability in regulating the drug release kinetics from drug-loaded
polymeric matrices.
Methods:
For this, Polydioxanone (PDS) was selected as the polymer and Paclitaxel (Ptx) as the model
drug. Two different forms of the matrix implants, viz., reservoir type capsules developed by dip
coating and matrix type membranes fabricated by phase inversion and electrospinning, were utilized
for the study. Drug release from all the four different matrices prepared by simple techniques was
evaluated in vitro in PBS and ex vivo in peritoneal wash fluid for ~4 weeks. The drug release profiles
were thereafter correlated with the physicochemical parameters of the polymeric implants.
Results:
Reservoir-type capsules followed a slow and steady zero-order kinetics, while matrix-type
electrospun and phase inversion membranes displayed typical biphasic kinetics.
Conclusion:
It was inferred that the slow degradation rate of PDS polymer as well as the implant
properties like porosity and wettability play an important role in controlling the drug release rates.
Funder
Department of Science and Technology of Government of India
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering