Affiliation:
1. Department of Pharmaceutics, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar
Pradesh, India
Abstract
Abstract:
Generally, therapeutic drugs have issues like poor solubility, rapid removal from the bloodstream,
lack of targeting, and an inability to translocate across cell membranes. Some of these barriers
can be overcome by using nano drug delivery systems (DDS), which results in more efficient drug delivery
to the site of action. Due to their potential application as drug delivery systems, nanoparticles
are the main topic of discussion in this article. Experimental and computational investigations have
substantially aided in the understanding of how nanocarriers work and how they interact with medications,
biomembranes and other biological components. This review explores how computational modelling
can aid in the rational design of DDS that has been optimized and improved upon. The most
commonly used simulation methods for studying DDS and some of the most important biophysical elements
of DDS are also discussed. Then, we conclude by investigating the computational properties of
various types of nanocarriers, such as dendrimers and dendrons, polymer-, peptide-, nucleic acid-, lipid-,
carbon-based DDS, and gold nanoparticles.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering
Cited by
3 articles.
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