The Role of Epigenetic Mechanisms in the Treatment of GI Cancers-Reference-Cited by-同舟云学术

The Role of Epigenetic Mechanisms in the Treatment of GI Cancers

Published:2024-06-28 Issue: Volume:24 Page:
ISSN:1568-0096
Container-title:Current Cancer Drug Targets
language:en
Short-container-title:CCDT

Author:

Shahini Ali¹,Imani Amirhossein¹²,Reyhani Amirali¹,Khalili-Tanha Ghazaleh³,Ghorbani Elnaz³⁴,Fiuji Hamid³,Saeed Al-Hayawi Ibrahim⁵,Khazaei Majid³⁴,Hassanian Seyed Mahdi¹,Ferns Gordon A.⁶,Nazari Elham³⁴,Avan Amir³⁵⁷⁸

Affiliation:

1. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4. Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

5. School of Mechanical, Medical and Process Engineering, Science and Engineering Faculty, Queensland University of Technology, 2 George St, Brisbane City QLD 4000, Australia

6. Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia

7. School of Mechanical, Medical and Process Engineering, Science and Engineering Faculty, Queensland University of Technology, 2 George St, Brisbane City QLD 4000,, Mashhad, Australia

8. Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane,, Australia

Abstract

Abstract: Epigenetic mechanisms have been shown to play a critical role in the development and progression of gastrointestinal [GI] cancers. These mechanisms involve modifications to DNA and histones that can alter gene expression patterns and may contribute to the initiation and progression of cancers. In recent years, epigenetic therapies have emerged as a promising approach to treating GI cancers. These therapies target specific epigenetic modifications, such as DNA methylation and histone acetylation, to restore normal gene expression patterns and inhibit cancer cell growth. Several epigenetic drugs have been approved for the treatment of GI cancers. Moreover, the use of epigenetic therapies in combination with other treatments, such as chemotherapeutic agents, is being studied to improve treatment outcomes. We have provided an overview of the role of epigenetic mechanisms in GI cancer treatment aimed to focus on recent evidence of the use of epigenetic agents in clinical and preclinical GI cancer studies, including gastric, esophageal, hepatic, pancreatic, and colorectal cancers. Overall, the role of epigenetic mechanisms in GI cancer treatments is an active area of research with the potential to improve patients' treatment outcomes and advance cancer treatment strategies.

Publisher

Bentham Science Publishers Ltd.