Affiliation:
1. Department of Biotechnology, Atmiya University, Rajkot, 360005, India
Abstract
Abstract:
CSCs (Cancer stem cells) are a subpopulation of transformed cells residing within the tumour that possesses
properties of stem cells, like self-renewal and differentiation. Different signalling pathways, epigenetic changes, and
interaction with a tumour microenvironment are found to be involved in the maintenance of stemness of CSCs and
contribute to chemoresistance. Hence, it is difficult to prevent and control progression completely without considering
CSCs as a crucial target. Some phytochemicals target different pathways and gene expression and modulate CSC
markers to suppress the stemness properties of cancer cells. Thus, phytochemicals potentially impact CSCs which may
be applied in chemo-prevention. This comprehensive review discusses some studied phytochemicals that suppress
stemness characters in various cancer types both in vitro and in vivo animal models. However, the chemo-prevention
ability of phytochemicals needs to be validated in further subsequent stages of clinical trials.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine