Affiliation:
1. Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, India
Abstract
Abstract:
Despite the substantial progress that has been made in cancer therapy over the past few decades, there has
been a discernible rise in the number of reported instances of carcinoma over the past few decades. Breast cancer especially
triple-negative breast cancer (TNBC), being the most common cancer found in females account for extensive
research. This type of cancer, which is responsible for more than 15% to 20% of all breast cancers, is particularly interesting
for research since it is difficult to treat due to its poor response to treatment and extremely aggressive nature. In
clinical practice, triple-negative breast cancer is characterized by a relatively high risk of disease recurrence and distant
metastasis, as well as a poor prognosis regarding overall survival. The goal of this review is to provide the recent advancement
of the therapeutic potential of N-heterocycles covering in vitro and in vivo activities for the treatment of
triple-negative breast cancer.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine