Recent Advances and Therapeutic Journey of Schiff Base Complexes with Selected Metals (Pt, Pd, Ag, Au) as Potent Anticancer Agents: A Review

Author:

Khan Sikandar1ORCID,Ibrahim Munjed M.2,Alhumaydhi Fahad A.3,Alqahtani Ali4,Alshamrani Meshal5,Alruwaili Abdullah S.6,Hassanian Athar A.7,Khan Sajad8

Affiliation:

1. Department of Chemistry, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan

2. Department of Pharmaceutical Chemistry, College of pharmacy, Umm Al-Qura University, 21955-Makkah, Kingdom of Saudi Arabia

3. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia

4. Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Kingdom of Saudi Arabia

5. Department of Pharmaceutics, College of Pharmacy, Jazan University, P.O. Box 114, Jazan 45142, Kingdom of Saudi Arabia

6. Department of Clinical Laboratory, College of Applied Medical Science, Northern Border University, P.O Box 1321, Ar’ar 9280, Kingdom of Saudi Arabia

7. Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia

8. Center of Biotechnology and Microbiology, Abdul Wali Khan University Mardan, Mardan, Khyber Pakhtunkhwa 23200, Pakistan

Abstract

Abstract: Schiff bases and their transition metal complexes play an important role in the field of medicine, in particular in the treatment of cancer. Since the discovery of the cisplatin anticancer activity, great efforts have focused on the rational design of metal-based anticancer drugs that can be potentially used for the treatment of cancer. However, drug resistance and significant side effects greatly limit its clinical application. This has inspired medicinal chemists to employ various strategies in the development of novel and effective anticancer drugs. Recently, a greater number of transition metal complexes have been designed and evaluated for their anticancer activities, and some of them were at different stages of clinical studies. Amongst these, platinum, palladium, gold and silver complexes have an important place within medicinal and inorganic chemistry. This review article discusses Schiff bases and their complexes with selected transition metals (Pd, Pt, Ag, Au) for anticancer activity against different cancer cell lines.

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Pharmacology,Molecular Medicine

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