Boosting Anti-tumour Immunity Using Adjuvant Apigenin

Author:

Xiao Chuli1,Najafi Masoud2,Huang Jun3,Chen Xuedong3,Chang Zaoshang3

Affiliation:

1. Shaoyang Key Laboratory of Molecular Biology Diagnosis, Shaoyang 422000, China

2. Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran

3. College of Basic Medicine, Shaoyang University, Shaoyang 422000, China

Abstract

Abstract: The interactions and secretions within the tumour have a pivotal role in tumour growth and therapy. Immunosuppressive cells such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), tumour-associated macrophages (TAMs), and cancer-associated fibroblasts (CAFs) secrets some substances, which can result in exhaustion of anti-tumour immunity. To stimulate anti-tumour immunity, suppression of the secretion and interactions of immunosuppressive cells, on the other hand, stimulation of proliferation and activation of natural killer (NK) cells and CD8+ T lymphocytes are required. Apigenin is a flavone with anticancer properties. Emerging evidence shows that not only does apigenin modulate cell death pathways in cancer cells but it also can stimulate anti-tumour immune cells to release death signals and suppress the release of tumour-promoting molecules. In this review, we discuss the interactions between apigenin and various cells within the tumour microenvironment (TME). These interactions may enhance anti-tumour immunity to improve the efficiency of anticancer remedies such as immunotherapy.

Funder

Scientific Research Project of Hunan Provincial Education Department

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Pharmacology,Molecular Medicine

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