Affiliation:
1. Department of Chemistry, University of Rajasthan, Jaipur 302004, Rajasthan, India
2. Department of Chemistry, Manipal Institute of
Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India
3. Department of Chemistry, Kanoria P.G. Mahila
Mahavidyalaya, Jaipur 302004, Rajasthan, India
Abstract
Background:
In recent years, there has been a crucial need for the design and development of novel anticancer
drugs that can lessen the serious health problems and unwanted side effects associated with currently used anticancer
drugs. The triazole nucleus is well-recognized to possess numerous pharmacological activities, including anticancer,
as revealed by various investigations on anticancer drugs and the latest research findings.
Objective:
The aim of this review article is to summarise the anticancer potential of 1, 2, 3-triazole, 1, 2, 4-triazole and
heterocycle-fused triazole derivatives against several human cancer cell lines, compiling research articles published
between 2010 and 2021.
Methods:
Data were collected from PubMed, Google scholar and Research Gate using keywords “anticancer activity
of 1, 2, 3-triazole derivatives”, “anticancer activity of 1, 2, 4-triazole derivatives” and “anticancer activity of heterocycle-
fused triazole derivatives” and reviewed comprehensively.
Results:
This review examines the anticancer potential of 1,2,3-triazole coupledoleanolic acid/dithiocarbamate/ pyrido[
2,3-d] pyrimidine derivatives, 1,2,3-triazole linked pyrimidine/1,4-naphthoquinone hybrids, and 1,2,4-triazole
substituted methanone derivatives, acridine-based 1,2,4-triazole derivatives, 1,2,4-thiadiazol coupled with 1,2,4-
triazole and 5-ene-thiazolo[3,2-b][1,2,4]triazole-6(5H)-one derivatives against several human cancer cell lines.
Conclusion:
This review highlights the key findings in the area of cancer therapy. Triazole derivatives possess anticancer
activity against various human cancer cell lines, and hence the triazole core may act as a lead molecule for the
synthesis of novel anticancer drugs.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine