Site-Specific Binding of Anti-Cancer Drugs to Human Serum Albumin-Reference-Cited by-同舟云学术

Site-Specific Binding of Anti-Cancer Drugs to Human Serum Albumin

Published:2022-08-04 Issue:16 Volume:22 Page:2876-2884
ISSN:1871-5206
Container-title:Anti-Cancer Agents in Medicinal Chemistry
language:en
Short-container-title:ACAMC

Author:

Jeelani Ishtiaq¹²,Bhosale Mrinalini³,Nawaz Allah²,Abe Hitoshi⁴,Padhye Subhash³

Affiliation:

1. Graduate School of Innovative Life Science, University of Toyama, Toyama 3190, Gofuku 930-8555, Japan

2. Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama 2630, Sugitani 930- 0194, Japan

3. Department of Chemistry, Abeda Inamdar Senior College of Arts, Science and Commerce, Savitribai Phule Pune University, Pune 411001, India

4. Faculty of Engineering, University of Toyama, Toyama 3190, Gofuku 930-8555, Japan

Abstract

Abstract: The interaction of drugs with proteins plays a very important role in the distribution of the drug. Human serum albumin (HSA) is the most abundant protein in the human body and showing great binding characteristics has gained a lot of importance pharmaceutically. It plays an essential role in the pharmacokinetics of a number of drugs and hence several reports are available on the interaction of drugs with HSA. It can bind to cancer drugs and thus it is crucial to look at the binding characteristics of these drugs with HSA. Herein we summarize the binding properties of some anti-cancer drugs by specifically looking into the binding site with HSA. The number of drugs binding at Sudlow's site I situated in subdomain II A is more than the drugs binding at Sudlow's site II.

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Pharmacology,Molecular Medicine

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