Affiliation:
1. Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
Abstract
Background:
Pancreatic Ductal Adenocarcinoma (PDAC) is the most common form of pancreatic
cancer and leading causes of pancreatic cancer death because of most PDAC patients with advanced unresectable
disease at that time, which is remarkably resistant to all forms of chemotherapy and radiotherapy.
Objective:
PDAC increases the social and patient's family burden. However, the PDAC pathogenesis is not
identified. We are trying to uncover the underlying mechanism in the future.
Methods:
In our research, the drug-resistant cell line was successfully induced in the vitro by progressive concentrations
of Afatinib, which we named it as BxPC3-AR.
Results:
It has been observed that the effect of autophagy was on the resistance of BxPC3-AR to Afatinib.
Conclusion:
It has been confirmed that autophagy plays a certain role in BxPC3-AR resistance to Afatinib. Our
findings provide a new perspective on the role of autophagy in pancreatic ductal adenocarcinoma.
Funder
Jiangsu Province’s Graduate Student Research Innovation Project
projects of Suzhou Technology Bureau
Natural Science Foundation of Jiangsu Province
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine
Cited by
2 articles.
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