Affiliation:
1. Department of Pharmacy, School of Medical & Allied Sciences, GD Goenka University, Gurugram, India
2. Department of Pharmaceutical Sciences, MD University, Rohtak, India
Abstract
Background:
Despite significant advancement in oncology research, cancer still poses one of the
leading causes of mortality worldwide. The increased incidences of cancer may be attributed to the limited
efficacy and disastrous side effects of conventional therapies like chemotherapy, radiotherapy and surgery. Azole
containing medicinal agents are known for plethora of medicinal properties, including anticancer potential.
Objective:
In this review, we highlighted azole containing natural products with anticancer potential from marine
sources.
Methods:
A comprehensive literature search was performed for writing the review. Updated views about various marine sponges,
cyanobacteria, tunicates and microalgae producing azole nucleus containing secondary metabolites with anticancer potential have been
discussed.
Results:
The present article describes the structural, chemical, and biological features of azoles containing
natural agents from marine sources with promising anti-cancer potential. Additionally, current challenges and
future perspectives of azoles in cancer prevention and treatment are also discussed.
Conclusion:
This review might encourage scientific community to explore marine sources for developing novel and potent azole
containing anti-cancer agents with better safety profile.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine
Cited by
10 articles.
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