Affiliation:
1. Medicine Department, College of Medicine, Taibah University, Maidna, Saudi Arabia
2. Medical Biochemistry and Molecular Biology Department, College of Medicine, Menoufia University, Menoufia, Egypt
3. Medical Biochemistry Department, College of Medicine, Taibah University, Maidna, Saudi Arabia
Abstract
<P>Background: Osteoporosis is a systemic skeletal disease characterized by
low bone mineral density. Vitamin D metabolism may play a pivotal role in its
pathophysiology.
</P><P>
Objectives: To determine the association between Vitamin D receptor gene
polymorphisms and bone density, as well as its relation to biochemical markers of bone
turnover, in a healthy Saudi female population.
</P><P>
Methods: A cross-sectional study was carried out at Taibah University, Madinah
Region, Kingdom of Saudi Arabia. After receiving informed consent, blood samples from
300 subjects were collected to measure calcium, phosphorus, alkaline phosphatase,
parathyroid hormone osteocalcin, and 1,25-OHD and perform genetic analysis of SNPs
in vitamin D receptors (VDR) rs2228570, rs731236, and rs11568820.
</P><P>
Results: There were significant differences between the CC, CT, and TT alleles of VDR
rs2228570. Carrying the TT allele was associated with increased risks of decreased
bone density and the presence of osteopenia with lower vitamin D3 levels (p≤0.001).
The VDR rs731236 gene showed that CC allele carriers had significant risk of
osteopenia. The AA genotype of rs11568820 showed lower levels of physical activity,
bone mineral density, Z scores, serum osteocalcin, phosphorus, and parathyroid
hormones.
</P><P>
Conclusion: The presence of the TT allele of the SNP rs2228570 of the VDR gene and
the SNP rs731236 of the CC genotype was associated with the presence of osteopenia
and decreased bone mineral density alongside malfunctions of vitamin D.</P>
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry
Reference29 articles.
1. Miller PD, Siris ES, Barrett-Connor E. Prediction of fracture risk in postmenopausal white women with peripheral bone densitometry: evidence from the National Osteoporosis Risk Assessment.
2. Horst-Sikorska W, Dytfeld J, Wawrzyniak A. Vitamin D receptor gene polymorphisms, bone mineral density and fractures in postmenopausal women with osteoporosis.
3. . Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A. Tosteson A. Incidence and economic burden of osteoporosisrelated fractures in the United States, 2005-2025. J Bone Miner Res 2007; 22: 465-75.
4. . Bubshait D, Sadat-Ali M. Economic implications of osteoporosis-related femoral fractures in Saudi Arabian Society. Calcif Tissue Int 2007; 81: 455-8.
5. Ardawi AA, Maimany TM. Bahksh Han, Nasrat WA, Milaat RM, Al-Raddadi A. Bone mineral density of the spine and femur in healthy Saudis.
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献