Affiliation:
1. Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Mangalagiri-522503, Guntur, Andhra Pradesh, India
2. Department of Otorhinolaryngology, Katuri Medical College and Hospital, Guntur, Andhra Pradesh, India
Abstract
Male infertility is rising nowadays and accounts for a major part of infertility
cases worldwide. Novel tests are being developed for better detection and management
of male infertility. Though there are many tests available for diagnosing male infertility
like acrosome reaction rate, hemizona assay, in vivo or in vitro sperm penetration assay,
sperm DNA damage tests, however, a semen analysis is the most commonly used initial
test for male infertility. It is usually associated with failure to detect the cause in many
cases, as seminal composition gets affected by a number of factors and can give false
reports. Furthermore, it does not give any information about defects in capacitation,
sperm-zona pellucida interaction, and sperm’s ability to fertilize oocytes. This results in
failure of detection and delayed management of male infertility. Hence, the present
review was conducted to identify various sperm proteins that play a significant role in
spermatogenesis, sperm motility, sperm-zona pellucida interaction, and fertilization.
These proteins can be used in the future as markers of male infertility and will aid in
better detection and management of male infertility. Methodology: Search for literature
was made from 1970 to 2020 from various databases like PUBMED, SCOPUS, Google
Scholar on sperm proteins and their role in male fertility using keywords: “sperm protein
as bio-markers”, “novel sperm proteins as markers of infertility”, “Sperm proteins
essential for capacitation, sperm motility and oocyte fertilization”. Inclusion criteria: All
full-length research articles, systematic reviews, meta-analyses, or abstracts on sperm
proteins and male infertility published in the English language in peer-reviewed journals
were considered.
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry
Cited by
4 articles.
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