Leukaemia Infection Diagnosis and Intestinal Flora Disorder
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Published:2022-01
Issue:1
Volume:22
Page:2-7
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ISSN:1566-5240
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Container-title:Current Molecular Medicine
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language:en
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Short-container-title:CMM
Author:
Wang Hongwu1ORCID,
Zhong Yong2,
Ma Lian1
Affiliation:
1. Department of Hematology and Oncology, Shenzhen Children\'s Hospital of China Medical University,
Shenzhen, 518038, China
2. Department of paediatrics, The Southeast General Hospital of
Dongguan, Dongguan, 523000, China
Abstract
:
Leukaemia is the most common malignant tumor in childhood and can be cured by chemotherapy. Infection is an important cause of treatment-related death and treatment failure in childhood leukaemia. Recent studies have shown that the correlation between the occurrence of leukaemia infection and the intestinal flora has attracted more and more attention. Intestinal flora can affect the body's physiological defense and immune function. When intestinal microflora disorder occurs, metabolites/microorganisms related to intestinal flora alterations and even likely the associated morpho-functional alteration of the epithelial barrier may be promising diagnostic biomarkers for the early diagnosis of leukaemia infection. This review will focus on the interaction between leukaemia infection and intestinal flora, and the influence of intestinal flora in the occurrence and development of leukaemia infection.
Funder
National Natural Science Foundation of China
Science and technology projects of Guangdong Province
Science and Technology Planning Project of Shantou
promoting special projects of science and technology bureau in Dongguan
Shenzhen Key Projects of Basic Research
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry
Cited by
1 articles.
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