Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies-Reference-Cited by-同舟云学术

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Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies

Published:2021-12-03 Issue:8 Volume:18 Page:761-789
ISSN:1570-1794
Container-title:Current Organic Synthesis
language:en
Short-container-title:COS

Author:

Abedinifar Fahimeh¹^ORCID,Mahdavi Mohammad¹^ORCID,Asadi Mehdi¹^ORCID,Hamedifar Haleh²^ORCID,Ansari Samira²^ORCID,Larijani Bagher¹^ORCID

Affiliation:

1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176, Iran

2. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran

Abstract

Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.

Funder

National Institute for Medical Research Development

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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