Affiliation:
1. Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bibinagar-508126,
Hyderabad Metropolitan Region, Telangana, India
Abstract
Abstract:
Male infertility is a major issue, and numerous factors contribute to it. One of
the important organelles involved in the functioning of human spermatozoa is
mitochondria. There are 50-75 mitochondria helically arranged in mid-piece bearing one
mitochondrial DNA each. Sperm mitochondria play a crucial role in sperm functions,
including the energy production required for sperm motility and the production of reactive
oxygen species, which in the physiological range helps in sperm maturation,
capacitation, and acrosome reaction. It also plays a role in calcium signaling cascades,
intrinsic apoptosis, and sperm hyperactivation. Any structural or functional dysfunction of
sperm mitochondria results in increased production of reactive oxygen species and, a
state of oxidative stress, decreased energy production, all leading to sperm DNA
damage, impaired sperm motility and semen parameters, and reduced male fertility.
Furthermore, human sperm mitochondrial DNA mutations can result in impaired sperm
motility and parameters leading to male infertility. Numerous types of point mutations,
deletions, and missense mutations have been identified in mtDNA that are linked with
male infertility.
Methods:
Recent literature was searched from English language peer-reviewed journals
from databases including PubMed, Scopus, EMBASE, Scholar, and Web of Science till
September 2021. Search terms used were “Sperm mitochondria and male fertility”,
“Bioenergetics of sperm”, “Sperm mitochondria and reactive oxygen species”, “Sperm
mitochondrial mutations and infertility”.
Conclusion:
Sperm mitochondria is an important organelle involved in various functions
of human spermatozoa and sperm mitochondrial DNA has emerged as one of the potent
biomarkers of sperm quality and male fertility.
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献