Mesenchymal Stem Cell-derived Exosomes Affect Macrophage Phenotype: A Cell-free Strategy for the Treatment of Skeletal Muscle Disorders

Author:

Wu Yucheng1,Su Gang2ORCID,Lei Xiaoting1,Wang Zhenyu1,Xie Weiqiang1,Wen Donghong1

Affiliation:

1. Department of Orthopedics, The First People's Hospital of Tianshui City, Tianshui, China

2. Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China

Abstract

Abstract: The process of tissue damage, repair, and regeneration in the skeletal muscle system involves complex inflammatory processes. Factors released in the inflammatory microenvironment can affect the phenotypic changes of macrophages, thereby changing the inflammatory process, making macrophages an important target for tissue repair treatment. Mesenchymal stem cells exert anti-inflammatory effects by regulating immune cells. In particular, exosomes secreted by mesenchymal stem cells have become a new cell-free treatment strategy due to their low tumorigenicity and immunogenicity. This article focuses on the mechanism of the effect of exosomes derived from mesenchymal stem cells on the phenotype of macrophages after skeletal muscle system injury and explores the possible mechanism of macrophages as potential therapeutic targets after tissue injury.

Funder

KNC Key Laboratory of Gastrointestinal Tumors Diagnosis and Treatment Open Project

Natural Science Foundation of Science and Technology Department of Gansu Province

Lanzhou University Second Hospital Cuiying Technology Innovation Program Project

National Natural Science Foundation of China

Lanzhou University Second Hospital

Publisher

Bentham Science Publishers Ltd.

Subject

Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

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