Covid-19 prevention and treatment by targeting Fc-fusion proteins: An experience to fight emerging diseases-Reference-Cited by-同舟云学术

Covid-19 prevention and treatment by targeting Fc-fusion proteins: An experience to fight emerging diseases

Published:2023-04-10 Issue: Volume:23 Page:
ISSN:1566-5240
Container-title:Current Molecular Medicine
language:en
Short-container-title:CMM

Author:

Ghasemi Fahimeh¹²,Zare Hamed³,Farkhondeh Tahereh⁴,Bakherad Hamid⁵,Sharifi Hengame⁶,Hosseinzade Shirzeyli Maryam⁷,Samarghandian Saeed⁸

Affiliation:

1. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran

2. Medical biotechnology department, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran

3. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

4. Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran

5. Department of Pharmaceutical Biotechnology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

6. Department of Molecular Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran

7. Department of Anatomical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

8. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur. Iran

Abstract

Abstract: The coronavirus disease 2019 (Covid-19) pandemic has been considered a major threat to human health. Effective therapeutic approaches are urgently required. Spike protein and the Angiotensin-converting enzyme 2 (ACE2) receptors have critical roles in SARS-CoV-2 infection. As a result, these two proteins are considered potential targets for the development of a wide variety of biotherapeutics and vaccines for controlling Covid-19. The fusion proteins have desirable medicinal properties, including high serum half-life, stability, and solubility in the body. Moreover, other Fc-fusion proteins used to treat other diseases have no known side effects. These Fc-fusion proteins are valuable biopharmaceuticals and have been proposed as therapeutic candidates for the treatment and prevention of Covid-19 owing to their potential therapeutic benefits.

Publisher

Bentham Science Publishers Ltd.

Subject

Molecular Biology,Molecular Medicine,General Medicine,Biochemistry