Research Update on the Pathophysiological Mechanisms of Heart Failure with Preserved Ejection Fraction

Abstract

: Heart failure (HF) is a serious clinical syndrome, usually occurs at advanced stage of various cardiovascular diseases, featured by high mortality and rehospitalization rate. According to left ventricular (LV) ejection fraction (LVEF), HF has been categorized as HF with reduced EF (HFrEF; LVEF<40%), HF with mid-range EF (HFmrEF; LVEF 40-49%), and HF with preserved EF (HFpEF; LVEF ≥50%). HFpEF accounts for about 50% cases of heart failure, and has become the dominant form of heart failure. The mortality of HFpEF is similar as that of HFrEF. There are no well-documented treatment options that can reduce the morbidity and mortality of HFpEF now. Understanding the underlying pathological mechanisms are essential for the development of novel effective therapy options for HFpEF. In recent years, significant research progress has been achieved on the pathophysiological mechanism of HFpEF. This review aimed to update the research progress on the pathophysiological mechanism of HFpEF.