Obesity and Insulin Resistance: A Review of Molecular Interactions

Author:

Yaribeygi Habib1,Maleki Mina2,Sathyapalan Thozhukat3,Jamialahmadi Tannaz4,Sahebkar Amirhossein5

Affiliation:

1. Research Center of Physiology, Semnan University of Medical Sciences, Semnan,Iran

2. Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran,Iran

3. Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull,United Kingdom

4. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan,Iran

5. Halal Research Center of IRI, FDA, Tehran,Iran

Abstract

The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. An increase in sedentary lifestyle and consumption of a more energydense diet increased the incidence of obesity which is a significant risk factor for type 2 diabetes. Obesity acts as a potent upstream event that promotes molecular mechanisms involved in insulin resistance and diabetes mellitus. However, the exact molecular mechanisms between obesity and diabetes are not clearly understood. In the current study, we have reviewed the molecular interactions between obesity and type 2 diabetes.

Publisher

Bentham Science Publishers Ltd.

Subject

Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

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