Author:
Wihastuti Titin A.,Aini Fitria N.,Lutfiana Nurul C.,Heriansyah Teuku,Zamrudah Nafisatuz
Abstract
Objective:
This study is aimed to examine the expression of ICAM-1 and VCAM-1 in cardiac tissue of dyslipidemic Sprague Dawley rats.
Methods:
Eight Sprague Dawley strain rats, with 150-200 gram body weight, were divided into two groups. The control group was fed a standard diet, the positive control group was fed a high-fat diet as our previous study for 8 weeks. The pattern of distribution of ICAM-1 and VCAM-1 in cardiac muscle cell was examined by immunofluorescence and observed with a confocal laser scanning microscope. Lipid profile was also examined at the end of the study.
Result:
Independent t-test showed no differences in ICAM-1 and VCAM-1 expression in cardiac muscle of hypercholesterol-diet-fed Sprague Dawley rat compared to control.
Conclusion:
The expression of ICAM-1 and VCAM-1 in cardiac muscle did not change after the onset of atherosclerosis.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine
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