Long Noncoding RNA: Function and Mechanism on Differentiation of Mesenchymal Stem Cells and Embryonic Stem Cells
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Published:2019-04-29
Issue:3
Volume:14
Page:259-267
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ISSN:1574-888X
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Container-title:Current Stem Cell Research & Therapy
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language:en
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Short-container-title:CSCR
Author:
Zhu Jian1, Wang Yitian1, Yu Wei1, Xia Kaishun1, Huang Yuluan2, Wang Junjie1, Liu Bing1, Tao Huimin1, Liang Chengzhen1, Li Fangcai1
Affiliation:
1. Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, #88 Jie Fang Road, Hangzhou, 310009, Zhejiang, China 2. Department of Gynecologic Oncology, Women`s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Abstract
Background:Long suspected as transcriptional noise, recently recognized, long non-coding
RNAs (lncRNAs) are emerging as an indicator, biomarker and therapy target in the physiologic and
pathologic process. Mesenchymal stem cells and embryonic stem cells are important source for normal
and therapeutic tissue repair. However, the mechanism of stem cell differentiation is not completely
understood. Research on lncRNAs may provide novel insights into the mechanism of differentiation
process of the stem cell which is important for the application of stem cell therapy. The lncRNAs field
is still very young, new insights into lncRNAs function are emerging to a greater understanding of biological
processes.
Objective:
In this review, we summarize the recent researches studying lncRNAs and illustrate how
they act in the differentiation of the mesenchymal stem cells and embryonic stem cells, and discuss
some future directions in this field.
Results:
Numerous lncRNAs were differentially expressed during differentiation of mesenchymal stem
cells and embryonic stem cells. LncRNAs were able to regulate the differentiation processes through
epigenetic regulation, transcription regulation and post-transcription regulation.
Conclusion:
LncRNAs are involved in the differentiation process of mesenchymal stem cells and embryonic
stem cells, and they could become promising indicator, biomarker and therapeutic targets in the
physiologic and pathologic process. However, the mechanisms of the role of lncRNAs still require further
investigation.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Reference102 articles.
1. Russell J, Lodge E, Andoniadou C. Neuroendocrinology, Basic research advances on pituitary stem cell function and regulation.,, 2018, 107,, 196-203, 2. Kim CS, Choi H, Park KC. Otolaryngol Head Neck Surg, The ability of human nasal inferior turbinate-derived mesenchymal stem cells to repair vocal fold injuries.,, 2018, 159,, 335-342, 3. Reich HJ, Czer LSC, Ramzy D. ASAIO J, Combining stem cell therapy for advanced heart failure and ventricular assist devices: A review.,, 2018, 64,, e80-e87, 4. Wezyk M, Szybinska A, Wojsiat J. J Alzheimers Dis, Overactive BRCA1 affects presenilin 1 in induced pluripotent stem cell-derived neurons in alzheimer’s disease.,, 2018, 62,, 175-202, 5. Ulyanova O, Baigenzhin A, Doskaliyev Z. Exp Clin Transplant, Transforming growth factor beta1 in Patients with type 2 diabetes mellitus after fetal pancreatic stem cell transplant.,, 2018, 16,, 168-170,
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