Affiliation:
1. Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail
University of Meknes, BP 509, Boutalamine, Errachidia, 52000, Morocco
2. Energy, materials and sustainable development
(EMDD) Team- Higher School of Technology-SALE, Center for Water, Natural Resources Environment and Sustainable
Development (CERNE2D), Mohammed V University in Rabat, Rabat, Morocco
Abstract
aims:
The goal of this study was to evaluate the antidiabetic effect of Rhamnus alaternus aqueous extract in streptozotocin(STZ)-induced diabetic rats.
background:
Traditionally, the aerial parts of Rhamnus alaternus L. have been widely used, in Mediterranean countries, including Morocco, for the cure of diabetes.
objective:
This work aimed to evaluate the antihyperglycemic effect of Rhamnus alaternus aqueous extract (RAAE) in normal and diabetic rats. Then the phytochemical composition, antioxidant capacity and the potential toxicity of RAAE were also assessed.
method:
The effects of the acute (6 h) and sub-chronic (7 days) oral administration of RAAE (20 mg/kg) on blood glucose levels and lipid profiles were evaluated in normal and diabetic rats. Besides, a preliminary phytochemical screening, quantification of phenolic, flavonoid and tannins contents as well as the antioxidant activity, using the DPPH method, were evaluated. Additionally, the toxicity of the aqueous extract (5 mg/kg) was also studied and the LD50 value was determined.
result:
RAAE (20 mg/kg) over 7 days of oral administration decreased significantly the blood glucose levels both in normal and diabetic rats. In diabetic rats, this extract was also able to improve oral glucose tolerance. In addition, RAAE possessed a significant antioxidant activity. According to preliminary phytochemical research, RAAE contains several chemical compounds, including alkaloids, polyphenols, flavonoids, cyanidins, anthraquinones and sterols. On the other hand, the quantitative phytochemical study of the aqueous extract revealed a considerable amount of total phenolic compounds (497.93±3.38 mg GAE/1 g of RAAE), flavonoids (100.42 ± 0.32 mg RE/ g of RAAE), and tannins (14.32 ± 0.37 mg CE/1g of RAAE).
conclusion:
We conclude that RAAE exerts a significant antihyperglycemic effect in STZ-induced diabetic rats at a low dose used. Indeed, more research is still required to support the use of this plant in the Moroccan population''s diabetes care.
other:
Not applicable
Funder
CNRST, Centre National pour la Recherche Scientifique et Technique
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology,Molecular Medicine,General Medicine
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