Antidiabetic Effect of Star Anise (Illicium verum) in Streptozotocin-induced Diabetic Rats-Reference-Cited by-同舟云学术

Antidiabetic Effect of Star Anise (Illicium verum) in Streptozotocin-induced Diabetic Rats

Published:2023-06 Issue:2 Volume:23 Page:92-98
ISSN:1871-529X
Container-title:Cardiovascular & Hematological Disorders-Drug Targets
language:en
Short-container-title:CHDDT

Author:

Amtaghri Smail¹²,Qabouche Adil¹,Slaoui Miloudia²,Eddouks Mohamed³

Affiliation:

1. Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia, 52000, Morocco

2. Energy, Materials and Sustainable Development (EMDD) Team- Higher School of Technology-SALE, Center for Water, Natural Resources Environment and Sustainable Development (CERNE2D), Mohammed V University in Rabat, Rabat, Morocco

3. Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia, 52000, Morocco;

Abstract

Aim: The current study aimed to evaluate the antidiabetic potential of Illicium verum fruits. Background: Illicium verum fruits are frequently used by the Moroccan population in the treatment of diabetes. Methods: The antihyperglycemic effect of the aqueous extract of Illicium verum fruits (AEIVF) in rats was assessed. The effects of AEIVF (20 mg/kg) on glycemia and lipid profile as well as its phytochemical and antioxidant properties were evaluated. Results: In normal and diabetic rats, AEIVF reduced blood glucose levels 6 hours after administration. Furthermore, after 7 days of treatment, glycemia was lowered in diabetic rats, and this extract exhibited an antioxidant activity. Conclusion: The study shows that Illicium verum possesses a potent antidiabetic activity. In addition, the toxicity of AEIVF was evaluated and the LD50 value was found to be greater than the 2 g/kg dose.

Funder

CNRST, Centre National pour la Recherche Scientifique et Technique

Publisher

Bentham Science Publishers Ltd.

Subject

Cardiology and Cardiovascular Medicine,Pharmacology,Hematology,Molecular Medicine,General Medicine

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