Affiliation:
1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)- Hyderabad, Bala Nagar, Hyderabad, TS, India
Abstract
Macrovascular complications of diabetes like cardiovascular diseases appear to be one of
the leading causes of mortality. Current therapies aimed at counteracting the adverse effects of
diabetes on cardiovascular system are found to be inadequate. Hence, there is a growing need in
search of novel targets. Adenosine Monophosphate Activated Protein Kinase (AMPK) is one such
promising target, as a plethora of evidences pointing to its cardioprotective role in pathological
milieu like cardiac hypertrophy, atherosclerosis and heart failure. AMPK is a serine-threonine
kinase, which gets activated in response to a cellular depriving energy status. It orchestrates cellular
metabolic response to energy demand and is, therefore, often referred to as “metabolic master
switch” of the cell. In this review, we provide an overview of patho-mechanisms of diabetic
cardiovascular disease; highlighting the role of AMPK in the regulation of this condition, followed
by a description of extrinsic modulators of AMPK as potential therapeutic tools.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology,Molecular Medicine,General Medicine
Cited by
7 articles.
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