Affiliation:
1. Chitkara College of Pharmacy, Chitkara University, Punjab, India
Abstract
Abstract:
One of the important parameters in the case of dosage form is taste. Most of the drugs
available in oral dosage form have an unpleasant taste which leads to patient incompliance and
affects the success ratio of products in the market. Geriatric and paediatric patients suffer more
with the bitter taste of medicines. According to the studies reported, it is found that 50% of the
population have the problem swallowing tablets, especially the pediatric and geriatric population.
Masking the taste of bitter drugs has become necessary in the pharmaceutical field and increasing
interest of researchers to develop various methods for masking the bitter taste of drugs. Five major
tastes, felt by our tongue are salt, sour, sweet, bitter, and umami. When the drug dissolves with
saliva, drug molecules interact with taste receptors present on the tongue and give taste sensations.
Although, many solid oral dosage forms like pills, and tablets have an additional advantage of
masking and encapsulation of bitter taste drugs; however, they might not be effective for children
because they may or may not swallow pills or tablets. There are various other methods that mask
the bitter taste of drugs such as the addition of sweeteners and flavouring agents, granulation, coating,
inclusion complexes, extrusion method, ion-exchange resins, etc, discussed in the first section
of the article. The second part of this article consists of various nanotechnology-based drug delivery
systems that were fabricated by researchers to mask the bitter taste of drugs. A brief of recent
literature on various nanocarriers that were fabricated or developed for taste masking has been
discussed in this part. A better understanding of these methods will help researchers and pharmaceutical
industries to develop novel drug delivery systems with improved taste masking properties.
Publisher
Bentham Science Publishers Ltd.
Subject
Psychiatry and Mental health
Cited by
5 articles.
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