Affiliation:
1. Chitkara College of Pharmacy, Chitkara University, Punjab, Rajpura, India
2. Department of Pharmaceutics, Delhi
Pharmaceutical Sciences and Research University, New Delhi, India
Abstract
Abstract:
Engulfing almost 537 million people, the most commonly occurring metabolic disorder,
diabetes mellitus, is emerging as an epidemic worldwide. Diabetes mellitus is identified as a heterogeneous
pathological condition that is marked by extreme hyperglycemic (glucose) levels
caused by reduced insulin sensitivity. Synthetic antidiabetic medications are widely commercialized
but have slowly expressed several inevitable side effects and limitations in treated diabetic
subjects. Researchers have been exploring herbal medicine due to its esteemed therapeutic effects.
WHO have enlisted almost 21,000 herbal components that have established therapeutic benefit.
Several herbs, most of them widely available, have been studied to extract their active phytoconstituents
that have effective diabetes management potential with the least risk factor for side effects
and acute toxicity. Though acceptable standardization, awareness, and clinical trials are yet
to be established before mainstreaming herbal formulation, preclinical studies have confirmed the
higher safety and efficacy of several extracted phytoconstituents and formulation in comparative
analysis with synthetic products. The authors have also discussed their opinions with regard to the
vast usability of herbal components along with the multi-target functionality of several phytoconstituents,
as well as the challenges faced for standardizing, formulating, and marketing herbal
medicines. Other than this, several cases of clinical trials showing effectivity of herbal antidiabetic
aid are mentioned. In this review, an attempt has been made to summarize the potential antidiabetic
herbs, marketed herbal formulations, and patented formulations that have established
therapeutic prospects to downregulate diabetic conditions.
Publisher
Bentham Science Publishers Ltd.
Subject
Psychiatry and Mental health