Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?-Reference-Cited by-同舟云学术

Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?

Published:2019-04-05 Issue:5 Volume:17 Page:447-458
ISSN:1570-159X
Container-title:Current Neuropharmacology
language:en
Short-container-title:CN

Author:

Aicua-Rapun Irene¹,André Pascal²,Novy Jan¹

Affiliation:

1. Department of Clinical Neurosciences, University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland

2. Division of Clinical Pharmacology, University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland

Abstract

Epilepsy is considered the most frequent severe neurological condition but most patients treated with medication become seizure free. The management of treatment, however, is highly empirical, mainly relying on observation. A closed-loop therapy for epilepsy would be very valuable for more efficient treatment regimens. Here we discuss monitoring treatment (therapeutic drug monitoring) and the potential developments in this field, as well as providing a review of potential biomarkers that could be used to monitor the disease activity. Finally, we consider the pharmacogenetic input in epilepsy treatment.

Funder

Swiss National Science Foundation

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),Psychiatry and Mental health,Clinical Neurology,Neurology,Pharmacology,General Medicine

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