Affiliation:
1. Experimental and Clinical Physiopathology Research Group CTS-1039; Department of Health Sciences, Faculty of Health Sciences; University of Jaen, Campus Universitario Las Lagunillas, Jaen, Spain
Abstract
Gliomas are the most frequent brain tumors in the adult population and unfortunately the
adjuvant therapies are not effective. Brain tumorigenesis has been related both to the increased levels
of free radicals as inductors of severe damages in healthy cells, but also with the reduced response
of endogenous enzyme and non-enzymatic antioxidant defenses. In turn, both processes
induce the change to malignant cells. In this review, we analyzed the role of the imbalance between
free radicals production and antioxidant mechanism in the development and progression of gliomas
but also the influence of redox status on the two major distinctive forms of programmed cell death
related to cancer: apoptosis and autophagy. These data may be the reference to the development of
new pharmacological options based on redox microenvironment for glioma treatment.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Clinical Neurology,Neurology,Pharmacology,General Medicine
Cited by
42 articles.
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