Affiliation:
1. Department of Chemistry, Chapra Government College, Affiliated to University of Kalyani, Nadia-741123, West Bengal,
India
2. Department of Chemistry, Muragachha Government College, Affiliated to University of Kalyani, Nadia-
741154, West Bengal, India
Abstract
Abstract:
Electro-organic synthesis, an atom-efficient, sustainable, mild process, permits an ecofriendly
and elegant green path to synthesize structurally complex, still valuable molecules, avoiding
the use of conventional harsh oxidizing and reducing agents and long-route reaction protocols. Being
one of the oldest forms of reaction setups in a laboratory, it deals with fundamental redox chemistry
through the direct application of electrical potential. Here flow of electrons acts as an oxidizing agent
at the anode at the same time reducing agent at the cathode, depending upon the requirement of the
reaction. Simultaneously, it minimizes the generation of reagent waste during the reaction. However,
electrifying organic synthesis plays more than preventing the waste footprint. This technology provides
an alternative roadmap through nonclassical bond disconnections to access desired target molecules
by cutting down a number of steps with the formation of apparently looking difficult bonds
with excellent regio-, chemo-and stereoselectivity. Hence, it emerges as an alternative and attractive
technique for the contemporary synthetic communities. Consequently, in recent years, multiple milestones
have been achieved in the electro-organic synthesis of fascinating natural products through
oxidative C-C bond formation, C-H/N-H functionalization, very rare oxidative N-N dimerization,
RCDA dimerization, etc. Thus, synthesis of extremely complex natural products through finding new
electro-synthetic route as a key methodology have become one of the alluring synthetic targets to
synthetic chemists because of their versatile utilities in medicine, agriculture, food, and cosmetic
industry. This review presents advances in electrochemistry in the total synthesis of 20 complex natural
products reported since 2013. Enabling synthetic steps are analyzed alongside innate advantages
as well as future prospects are speculated.
Publisher
Bentham Science Publishers Ltd.
Cited by
2 articles.
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