Systemic Lupus Erythematosus: Symptoms and Signs at Initial Presentations
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Published:2019-07-24
Issue:2
Volume:18
Page:142-150
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ISSN:1871-5230
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Container-title:Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
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language:en
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Short-container-title:AIAAMC
Author:
Metry Abdel Masieh1, Al Salmi Issa1, Al Balushi Farida2, Yousef Mohammed Abdalla1, Al Ismaili Faisal1, Hola Alan1, Hannawi Suad3
Affiliation:
1. The Renal Medicine Department, The Royal Hospital, Muscat, Oman 2. Rheumatology Department, The Royal Hospital, Muscat, Oman 3. Rheumatology Department, Ministry of Health and Prevention, Dubai 65522, United Arab Emirates
Abstract
Background:
Systemic Lupus Erythematosus (SLE) is an autoimmune multisystem
inflammatory condition that causes microvascular inflammation with the production of
various auto-antibodies that play a major role in its pathogenesis. SLE can affect both sexes,
all ages, and all ethnic groups with widespread geographical and socioeconomic backgrounds.
Asia encompasses people of many sociocultural backgrounds with diverse ethnic.
Objective:
Due to a lack of national epidemiological research, the incidence and prevalence
of SLE in Middle Eastern and Arab countries, have only recently been studied. This article
aims to explore the status of SLE in Oman and to record symptoms and signs of SLE at first
presentation.
Methodology:
Medical records of all patients diagnosed with SLE at the Royal Hospital from
2006 to 2014 were reviewed for information recorded at first visit. SLE diagnosis was based
on the American College of Rheumatology classification criteria; ACR97 (which includes the
clinical manifestation and laboratory evidence). Patients with SLE disease manifestations extrapolated
and analyzed.
:
There were 966 patients diagnosed with SLE during the period from 2006 to 2014. Mean
(SD) age at presentations was 35.5 (11.5) years. Majority of patients were female which constitutes
88.7% of the total SLE patients with mean age 27.6 (1.4) years.
Results:
Constitutional symptoms were found in 48.68 of SLE population including fatigue in
35.22%, and weight changes in 13.43%.
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The cutaneous manifestations that were present included malar rash 37.69%, photosensitivity
35.10%, discoid lupus 17.63%, and hair loss 39.29%.
:
Musculoskeletal manifestations were commonly seen among the studied population including
arthralgia in 68.75%, myalgia in 55.65%, arthritis in 48.31%, whilst myositis, tendon abnormalities
and avascular necrosis were found in only 2.47%, 0.31% and 1.98%. respectively.
Conclusion:
This is the first study of the symptoms and signs at initial clinical presentation of
SLE patients compared to other studies done regionally where most have focused on clinical
manifestations during the progression course of SLE. SLE manifestations may be related to
the differences in the genetic make-up of the patients who come from various ethnic groups
despite similar geography or sociocultural background, or to referral bias, as some studies
were performed in the nephrology units and others in the rheumatology units. There is a
pressing need to establish a nationwide and regional collaboration to establish LUPUS and to
put forward a strategic planning with each MOH to provide an easy and efficient report of
SLE cases and provide various effective management for such a debilitating syndrome.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,General Medicine,Immunology,Immunology and Allergy
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