Imidazo[4,5-b]Pyridines: From Kinase Inhibitors to more Diversified Biological Properties-Reference-Cited by-同舟云学术

Imidazo[4,5-b]Pyridines: From Kinase Inhibitors to more Diversified Biological Properties

Published:2024-02 Issue:5 Volume:31 Page:515-528
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Jarmoni Karim¹²,Misbahi Khalid²,Ferrières Vincent¹^ORCID

Affiliation:

1. Univ Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226 - ISCR, Rennes, 35000, France

2. Laboratoire de Chimie Organique Appliquée, Faculté des Sciences et Techniques, Université Sidi Mohammed Ben Abdallah, Fès, Maroc

Abstract

Abstract: Imidazo[4,5-b]pyridines are amongst the oldest known heteroaromatic derivatives. Their structural similarity with purine basis has however aroused the curiosity of biologists and resulted in the developments of innovative bioactive compounds. This review thus firstly describes the main synthetic ways currently used to produce imidazo[ 4,5-b]pyridine derivatives, and secondly gives examples of their potential, especially focusing on protein inhibition abilities, thus opening the way to applications as anti-cancer or antimicrobial agents.

Funder

French Ministry of the Foreign Office

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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