The Effect of Statins on the Differentiation and Function of Central Nervous System Cells-Reference-Cited by-同舟云学术

The Effect of Statins on the Differentiation and Function of Central Nervous System Cells

Published:2024-04 Issue:11 Volume:31 Page:1348-1360
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Chamani Sajjad¹,Mobasheri Leila²,Zerehpoosh Shadi³,Naghizadeh Ali¹,McCloskey Alice P.⁴,Rizzo Manfredi⁵,Jamialahmadi Tannaz⁶⁷,Sahebkar Amirhossein⁷⁸⁹¹⁰

Affiliation:

1. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran.

2. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3. Department of medical biotechnology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran

4. School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK

5. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, School of Medicine, University of Palermo, 90133, Palermo, Italy

6. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

9. School of Medicine, The University of Western Australia, Perth, Australia

10. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Abstract: Statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS), and Alzheimer’s disease (AD), has received increasing attention in recent years, both within the scientific community and in the media. This review aims to provide an updated discussion on the effects of statins on the differentiation and function of various nervous system cells, including neurons and glial cells. Additionally, the mechanisms of action and how different types of statins enter the CNS will be discussed.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry