Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP)
-
Published:2021-11-26
Issue:37
Volume:28
Page:7714-7728
-
ISSN:0929-8673
-
Container-title:Current Medicinal Chemistry
-
language:en
-
Short-container-title:CMC
Author:
Liang Xiao1ORCID,
Hou Xuben1ORCID,
Fang Hao1ORCID
Affiliation:
1. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Ji’nan, Shandong 250012, China
Abstract
Striatal-enriched protein tyrosine phosphatase (STEP) is exclusively expressed
in the central nervous system and regulates various neuronal signaling factors through the
dephosphorylation of different substrates. Dysregulated expression or uncontrollable enzymatic
activity of STEP contributes to neurological disorders such as Alzheimer's disease,
which makes it a promising pharmaceutical target. Herein, we have reviewed the
structure and biological functions of STEP, as well as the recent development of smallmolecule
STEP modulators. We hope this review will provide a reference for the further
development of more potent and selective STEP inhibitors for the treatment of nervous
system diseases.
Funder
Shandong Provincial Natural Science Foundation
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献