Affiliation:
1. Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China
Abstract
Considerable evidence has proved that disturbed cholesterol metabolism
played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions
were found in intrinsic renal cells of diabetic kidney disease patients and animal models,
causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions,
podocyte injury, and microalbuminuria of diabetic kidney disease. In this review,
we summarized the process of disturbed cholesterol metabolism and discussed how it induced
kidney dysfunction in diabetic kidney disease.
Funder
1.3.5 project for disciplines of excellence of West China Hospital, Sichuan University
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
7 articles.
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