Affiliation:
1. Center of 3D Printing & Organ Manufacturing, School of Fundamental Sciences, China Medical University (CMU), No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China
Abstract
End-stage liver diseases have long been a threat to human health, and so far,
the treatment of these diseases lacks effective means. Allogenic organ transplantation has
become the last straw for most of the patients with end-stage liver diseases. However, this
technique has been greatly limited by the serious shortage of donors and other factors,
such as immune rejection, drug syndrome, and high cost. Recently, the emergence of
three-dimensional (3D) bioprinting technologies, together with the magnetic resonance
imaging (MRI) and computed tomography (CT) techniques, has driven the rapid growth
of this field toward liver therapies. There are several basic requirements for liver 3D bioprinting.
From information collection of diseased livers, to 3D printing of liver substitutes
(containing the major structural, material and functional characters), and to clinical
applications, suitable ‘bioinks’ and ‘bioprinters’ have played essential roles. In this review,
we highlight the advanced ‘bioinks’ and ‘bioprinters’ that have been used for vascularized
and innervated liver tissue 3D bioprinting. Further studies for the incorporation of
biliary networks in the bioartificial livers have been emphasized. It is expected that when
all the bottle-neck problems for liver 3D bioprinting are solved, batch (i.e. mass) and personalized
production of bioartificial livers will make it very easy to treat end-stage liver
diseases.
Funder
National Natural Science Foundation of China
The 2018 Scientist Partners of China Medical University (CMU) and Shenyang Branch of Chinese Academy of Sciences
Key Research & Development Project of Liaoning Province
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
2 articles.
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